Biomarker identification for endometriosis as a target for real-time intraoperative fluorescent imaging: A new approach using transcriptomic analysis to broaden the search for potential biomarkers

Intra-operative fluorescent imaging of endometriosis could help to optimize surgical treatment. Potential biomarkers to use as target for endometriosis-binding fluorescent probes were identified using a new five-phase transcriptomics-based approach to broaden the search for biomarkers. Using publicly available datasets, a differentially...

Multiscale gradient computation for flow in heterogeneous porous media

An efficient multiscale (MS) gradient computation method for subsurface flow management and optimization is introduced. The general, algebraic framework allows for the calculation of gradients using both the Direct and Adjoint derivative methods. The framework also allows for the utilization of any MS formulation that can be algebraically...

Adjoint formulation and constraint handling for gradient-based optimization of compositional reservoir flow

An adjoint formulation for the gradient-based optimization of oil-gas compositional reservoir simulation problems is presented. The method is implemented within an automatic differentiation-based compositional flow simulator (Stanford's AD-GPRS). The development of adjoint procedures for general compositional problems is much more challenging...