Computational analysis of copy number profiles of tumors

Cancer is a genetic disease. The activation, alteration or deactivation of cancer genes can stimulate undesirable cell-proliferation. Cancer genes can be subdivided into oncogenes and tumor suppressors. Oncogenes, such as growth factor receptors, are altered and/or overexpressed genes that are causally linked to tumorigenesis. Tumor suppressors,...

Mouse models in the era of large human tumour sequencing studies

Cancer is a complex disease in which cells progressively accumulate mutations disrupting their cellular processes. A fraction of these mutations drive tumourigenesis by affecting oncogenes or tumour suppressor genes, but many mutations are passengers with no clear contribution to tumour development. The advancement of DNA and RNA sequencing...