Adaptation of the Recreovía During COVID-19 Lockdowns: Making Physical Activity Accessible to Older Adults in Bogotá, Colombia

The community restrictions during the coronavirus disease 2019 pandemic adversely impacted older adults’ physical activity levels. This convergent mixed-method study assessed the adaptation of the Recreovía, a community-based physical activity program in Bogotá, and characterized physical activity levels among older adult participants. Our...

Monitoring the Well-being of Older People by Energy Usage Patterns: Systematic Review of the Literature and Evidence Synthesis

Background: Due to the aging population, there is a need for monitoring well-being and safety while living independently. A low-intrusive monitoring system is based on a person’s use of energy or water. Objective: The study's objective was to provide a systematic overview of studies that monitor the health and well-being of older people using...

Healthy Ageing: Design as a tool supporting prevention of modern diseases among middle-aged people

Ageing of the population is one of the most significant changes taking place in the population of the Netherlands, that will affect the dwelling design in the coming decades. This is also reflected by other phenomenon: together with the higher life expectancy, the quality of the lifetime deteriorates, of which the leading cause are chronic...

PLIS: A metabolomic response monitor to a lifestyle intervention study in older adults

The response to lifestyle intervention studies is often heterogeneous, especially in older adults. Subtle responses that may represent a health gain for individuals are not always detected by classical health variables, stressing the need for novel biomarkers that detect intermediate changes in metabolic, inflammatory, and immunity-related...

Polygenic Risk Score of Longevity Predicts Longer Survival across an Age Continuum

Studying the genome of centenarians may give insights into the molecular mechanisms underlying extreme human longevity and the escape of age-related diseases. Here, we set out to construct polygenic risk scores (PRSs) for longevity and to investigate the functions of longevity-associated variants. Using a cohort of centenarians with...

IL7R gene expression network associates with human healthy ageing