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van Gemert, Y. (author), Kozijn, A. E. (author), Pouwer, M. G. (author), Kruisbergen, N. N.L. (author), van den Bosch, M. H.J. (author), Blom, A.B. (author), Pieterman, E. J. (author), Weinans, Harrie (author), Stoop, R. (author), Princen, H. M.G. (author), van Lent, P. L.E.M. (author)Objective: High systemic cholesterol levels have been associated with osteoarthritis (OA) development. Therefore, cholesterol lowering by statins has been suggested as a potential treatment for OA. We investigated whether therapeutic high-intensive cholesterol-lowering attenuated OA development in dyslipidemic APOE∗3Leiden.CETP mice. Methods:...journal article 2021
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Klarenbeek, Sjoerd (author), Doornebal, Chris W. (author), Kas, Sjors M. (author), Bonzanni, Nicola (author), Bhin, Jinhyuk (author), Braumuller, Tanya M. (author), van der Heijden, Ingrid (author), de Bruijn, Roebi (author), Wessels, L.F.A. (author)Effective treatment of invasive lobular carcinoma (ILC) of the breast is hampered by late detection, invasive growth, distant metastasis, and poor response to chemotherapy. Phosphoinositide 3-kinase (PI3K) signaling, one of the major druggable oncogenic signaling networks, is frequently activated in ILC. We investigated treatment response and...journal article 2020
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De Ruiter, J. R. (author), Wessels, L.F.A. (author), Jonkers, J. (author)Cancer is a complex disease in which cells progressively accumulate mutations disrupting their cellular processes. A fraction of these mutations drive tumourigenesis by affecting oncogenes or tumour suppressor genes, but many mutations are passengers with no clear contribution to tumour development. The advancement of DNA and RNA sequencing...review 2018
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Redeker, Anke (author), Remmerswaal, Ester B.M. (author), van der Gracht, Esmé T.I. (author), Welten, Suzanne P.M. (author), Höllt, T. (author), Koning, Frits (author), Cicin-Sain, Luka (author), Nikolich-Žugich, Janko (author), ten Berge, Ineke J.M. (author), van Lier, René A. W. (author), van Unen, Vincent (author), Arens, Ramon (author)The relationship between human cytomegalovirus (HCMV) infections and accelerated immune senescence is controversial. Whereas some studies reported a CMV-associated impaired capacity to control heterologous infections at old age, other studies could not confirm this. We hypothesized that these discrepancies might relate to the variability in the...journal article 2018