Searched for: subject%3A%22mutation%22
(1 - 20 of 33)

Pages

List view
Grid view
document
Borg, Jonathan (author)
Double-strand break (DSB) repair is a critical cellular process which repairs breaks in both strands of the DNA double helix. Different repair mechanisms are tasked with repairing such breaks. Predicting deficiencies in repair mechanisms has been widely used for therapeutic purposes, such as targeting cancer cells that have specific DNA repair...
master thesis 2023
document
Zhang, M. (author)
A remarkable accomplishment of human beings in recent centuries is the extension of their average lifespan, for example by improved living conditions. A downside of this achievement is that aging-related diseases, such as Alzheimer’s disease (AD), have risen, and as a consequence are impacting the lives of an increasing fraction of individuals....
doctoral thesis 2023
document
Gil Jimenez, A. (author), van Dorp, Jeroen (author), Contreras-Sanz, Alberto (author), van der Vos, Kristan (author), Vis, Daniel J. (author), Braaf, Linde (author), Broeks, Annegien (author), Kerkhoven, Ron (author), van Kessel, Kim E.M. (author), Wessels, L.F.A. (author)
Cisplatin-based neoadjuvant chemotherapy (NAC) followed by radical cystectomy is recommended for patients with muscle-invasive bladder cancer (MIBC). It has been shown that somatic deleterious mutations in ERCC2, gain-of-function mutations in ERBB2, and alterations in ATM, RB1, and FANCC are correlated with pathological response to NAC in...
journal article 2023
document
Sarkar, A. (author), Al-Ars, Z. (author), Bertels, K.L.M. (author)
In this research, we extend the universal reinforcement learning agent models of artificial general intelligence to quantum environments. The utility function of a classical exploratory stochastic Knowledge Seeking Agent, KL-KSA, is generalized to distance measures from quantum information theory on density matrices. Quantum process...
conference paper 2023
document
Maessen, Rosa (author)
In this research, we examined the occurrence of skill mutation when propagating a collaborative sawing task from robot-to-robot. We conducted this research, to gain insight into this mutation to understand the generation of potentially beneficial or dangerous skills.<br/>Thirty propagation steps in simulation were conducted per experiment, each...
master thesis 2022
document
BRAEKMAN, THEO (author)
This project is about transforming existing buildings that are facing demolition. In opposition to the constant renewing of our physical world for better performing building, this graduation proposes a gradual mutation of a locality.
master thesis 2022
document
de Brouwer, Rik (author)
This project is about transforming existing buildings that are facing demolition. In opposition to the constant renewing of our physical world for better performing building, this graduation proposes a gradual mutation of a locality.
master thesis 2022
document
de Valk, S.C. (author), Mans, R. (author)
A major challenge in the research of transport proteins is to understand how single amino acid residues contribute to their structure and biological function. Amino acid substitutions that result in a selective advantage in adaptive laboratory evolution experiments can provide valuable hints at their role in transport proteins. In this study, we...
journal article 2022
document
Huang, Olivia (author)
Motivation: As one of the most common and life-threatening diseases in humans, cancer is a result of the accumulation of somatic mutations throughout the life cycle. Somatic mutation is a joint result of DNA lesion, which is a result of damage on DNA caused by mutagen, and the failure of DNA repair mechanisms. Therefore, understanding the...
master thesis 2021
document
Oudemans, Melchior (author)
The big data technology market size is expected to grow in the coming years. The advantages of having automated test tools for big data applications are becoming increasingly important. Fuzzing is an automated testing method which has been used in many different fields, but has not been frequently used in the big data domain as it poses several...
bachelor thesis 2021
document
van Koetsveld van Ankeren, Lars (author)
As the amount of data worldwide continues to grow the big data field is becoming increasingly important. Fuzz testing has shown to be an effective testing tool, and recent work has applied fuzz testing to big data applications. This study aims to contribute to knowledge on fuzz testing big data applications by extending on BigFuzz, a state-of...
bachelor thesis 2021
document
Agarwal, Swastik (author)
Unit testing is crucial for any software project. Writing these tests manually, however, can be quite cumbersome. To tackle this, automated testing has been growing in recent times. Unfortunately, most automated testing tools are a challenge to use. The TestCube Project intends to change that. They aim to make automated testing tools easy and...
bachelor thesis 2021
document
Zhu, Q. (author), Zaidman, A.E. (author), Panichella, A. (author)
Mutation testing is well-known for its efficacy in assessing test quality, and starting to be applied in the industry. However, what should a developer do when confronted with a low mutation score? Should the test suite be plainly reinforced to increase the mutation score, or should the production code be improved as well, to make the...
journal article 2021
document
Panichella, A. (author), Liem, C.C.S. (author)
Mutation testing is a well-established technique for assessing a test suite’s quality by injecting artificial faults into production code. In recent years, mutation testing has been extended to machine learning (ML) systems, and deep learning (DL) in particular; researchers have proposed approaches, tools, and statistically sound heuristics to...
conference paper 2021
document
Baciu, D.C. (author)
Creativity is everywhere. Diversity is everywhere. Digitization is everywhere. This present article gives a new perspective on my and my laboratory's work over the last decade, explaining why creativity, diversity, and digitization go everywhere together.
journal article 2021
document
Zhu, Q. (author)
The main goal of this thesis is to investigate, improve and extend the applicability of mutation testing. To seek the potential directions of how to improve and extend the applicability of mutation testing, we have started with a systematic literature review on the current state of how mutation testing is applied. The results from the systematic...
doctoral thesis 2020
document
Perli, T. (author), Moonen, Dewi P.I. (author), van den Broek, M.A. (author), Pronk, J.T. (author), Daran, J.G. (author)
Quantitative physiological studies on Saccharomyces cerevisiae commonly use synthetic media (SM) that contain a set of water-soluble growth factors that, based on their roles in human nutrition, are referred to as B vitamins. Previous work demonstrated that in S. cerevisiae CEN. PK113-7D, requirements for biotin were eliminated by laboratory...
journal article 2020
document
Kifetew, Fitsum (author), Devroey, Xavier (author), Rueda, Urko (author)
We report on the results of the seventh edition of the JUnit tool competition. This year, four tools were executed on a benchmark with (i) new classes, selected from real-world software projects, and (ii) challenging classes from the previous edition. We use Randoop and manual test suites from the projects as baselines. Given the interesting...
conference paper 2019
document
Vossen, David M. (author), Verhagen, Caroline V.M. (author), van der Heijden, Martijn (author), Essers, Paul B.M. (author), Bartelink, Harry (author), Verheij, Marcel (author), Wessels, L.F.A. (author), van den Brekel, Michiel W.M. (author), Vens, Conchita (author)
About half of advanced stage head and neck squamous cell carcinoma (HNSCC) patients can be cured by chemoradiotherapy. Patient outcome may be partially determined by the genetic alterations in HNSCC, rendering these alterations promising candidate prognostic factors and/or therapeutic targets. However, their relevance in patient outcome...
journal article 2019
document
Zhu, Q. (author), Panichella, A. (author), Zaidman, A.E. (author)
Mutation testing has been very actively investigated by researchers since the 1970s, and remarkable advances have been achieved in its concepts, theory, technology, and empirical evidence. While the most influential realisations have been summarised by existing literature reviews, we lack insight into how mutation testing is actually applied....
journal article 2018
Searched for: subject%3A%22mutation%22
(1 - 20 of 33)

Pages

List view
Grid view