Quantifying myocardial perfusion using 3D magnetic resonance imaging

Myocardial perfusion, the blood flow to the heart muscle, can be evaluated by tracing the passage of a contrast agent using cardiac magnetic resonance (CMR) imaging. This technique, well-established for diagnosing coronary artery disease, is limited by the necessity for breath-holding, subjective assessment, and low myocardial coverage. In this...

Higher Order Singular Value Decomposition Filter for Contrast Echocardiography

Assessing the coronary circulation with contrast-enhanced echocardiography has high clinical relevance. However, it is not being routinely performed in clinical practice because the current clinical tools generally cannot provide adequate image quality. The contrast agent's visibility in the myocardium is generally poor, impaired by motion...

Signal intensity informed multi-coil encoding operator for physics-guided deep learning reconstruction of highly accelerated myocardial perfusion CMR

Purpose: To develop a physics-guided deep learning (PG-DL) reconstruction strategy based on a signal intensity informed multi-coil (SIIM) encoding operator for highly-accelerated simultaneous multislice (SMS) myocardial perfusion cardiac MRI (CMR). Methods: First-pass perfusion CMR acquires highly-accelerated images with dynamically varying...

High-Resolution Free-Breathing Quantitative First-Pass Perfusion Cardiac MR Using Dual-Echo Dixon With Spatio-Temporal Acceleration

Introduction: To develop and test the feasibility of free-breathing (FB), high-resolution quantitative first-pass perfusion cardiac MR (FPP-CMR) using dual-echo Dixon (FOSTERS; Fat-water separation for mOtion-corrected Spatio-TEmporally accelerated myocardial peRfuSion). Materials and Methods: FOSTERS was performed in FB using a dual...

Improved Simultaneous Multi-Slice Imaging for Perfusion Cardiac MRI Using Outer Volume Suppression and Regularized Reconstruction

Perfusion cardiac MRI (CMR) is a radiation-free and noninvasive imaging tool which has gained increasing interest for the diagnosis of coronary artery disease. However, resolution and coverage are limited in perfusion CMR due to the necessity of single snap-shot imaging during the first-pass of a contrast agent. Simultaneous multi-slice (SMS)...

Pixel-wise assessment of cardiovascular magnetic resonance first-pass perfusion using a cardiac phantom mimicking transmural myocardial perfusion gradients

Purpose: Cardiovascular magnetic resonance first-pass perfusion for the pixel-wise detection of coronary artery disease is rapidly becoming the clinical standard, yet no widely available method exists for its assessment and validation. This study introduces a novel phantom capable of generating spatially dependent flow values to enable...

Degradation of myocardial perfusion SPECT images caused by contaminants in thallous (201Tl) chloride

Purpose Thallous (201Tl) chloride is a single-photon emission computed tomography (SPECT) tracer mainly used for assessing perfusion and viability of myocardial tissue. 201Tl emits X-rays around 72 keV and gammas at 167 keV, and has a half-life of 73 h. Regulations allow an intrinsic contamination up to 3–5%, which is mainly caused by 200Tl (368...