Bacterial adherence on 3-D printed plasma electrolytic oxidized titanium implants in dynamic conditions

Osteoarthritis, the degeneration of articular cartilage, which causes loss of mobility and chronic pain for patients is a common condition with high clinical demand. Care of this condition currently attributes to ±1.4% of the Dutch annual health care costs, but due to the rapidly aging Dutch population a 41% increase of cases is projected over...

Effects of silver nanoparticle- containing 3D printed antibacterial implants on macrophages

Orthopedic implants used for total joint replacements are under a high clinical demand. Although most total joint replacements are successful, premature failures are still affecting tens of thousands of people annually. The major causes of implant failure are aseptic loosening and bacterial infections. To overcome these issues, multifunctional...

Antibacterial Surfaces Bearing Silver and Zinc Nanoparticles on Additively Manufactured Titanium Implants

The emergence of antibiotic-resistant bacteria has increased the number of implant revision procedures in the Netherlands due to implant-associated infections (IAI). Staphylococci strains accounted for more than 50% of all IAI cases. Preventative measure, such as active antibacterial surfaces on the implant, are urgently needed. This study aims...