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Fugazzola, Maria C. (author), Golafshan, Nasim (author), van Aken, Joris A. (author), Plomp, S. (author), De Grauw, Janny (author), van Buul, Ward (author), Hermsen, Gied (author), Weinans, Harrie (author), Castilho, Miguel (author), van Weeren, René (author), Malda, Jos (author)Summary: The objective of this study was to evaluate a non-resorbable implant for the focal repair of osteochondral defects. Enhanced adherence of repair cartilage overgrowing the implants was the secondary goal and was tested by introducing porosities on the articular surface of the implant. This study evaluated four versions of the...journal article 2023
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Arbabi, Saeed (author), Foppen, Wouter (author), Gielis, Willem Paul (author), van Stralen, Marijn (author), Jansen, Mylène (author), Arbabi, Vahid (author), de Jong, Pim A. (author), Weinans, Harrie (author), Seevinck, Peter (author)Magnetic resonance Imaging is the gold standard for assessment of soft tissues; however, X-ray-based techniques are required for evaluating bone-related pathologies. This study evaluated the performance of synthetic computed tomography (sCT), a novel MRI-based bone visualization technique, compared with CT, for the scoring of knee...journal article 2023
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Warmink, Kelly (author), Vinod, Prateeksha (author), Korthagen, Nicoline M. (author), Weinans, Harrie (author), Rios, Jaqueline L. (author)Osteoarthritis (OA) is a common and debilitating joint disorder that leads to progressive joint breakdown and loss of articular cartilage. Accompanied by a state of low-grade inflammation, its etiology extends beyond that of a wear-and-tear disease, and the immune system might have a role in its initiation and progression. Obesity, which is...review 2023
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Rayegan, H. (author), Nguyen, H. C. (author), Weinans, Harrie (author), Gielis, W. P. (author), Ahmadi Brooghani, S. Y. (author), Custers, R. J.H. (author), van Egmond, N. (author), Lindner, C. (author), Arbabi, V. (author)Objective: Herewith, we report the development of Orthopedic Digital Image Analysis (ODIA) software that is developed to obtain quantitative measurements of knee osteoarthritis (OA) radiographs automatically. Manual segmentation and measurement of OA parameters currently hamper large-cohort analyses, and therefore, automated and reproducible...journal article 2023
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Warmink, K. (author), Rios, J. L. (author), van Valkengoed, D. R. (author), Vinod, P. (author), Korthagen, N. M. (author), Weinans, Harrie (author)Introduction: Obesogenic diets aggravate osteoarthritis (OA) by inducing low-grade systemic inflammation, and diet composition may affect OA severity. Here, we investigated the effect of diet on joint damage and inflammation in an OA rat model. Methods: Wistar-Han rats (n = 24) were fed a chow, a high-fat (HF) diet, or a high-fat/high-sucrose...journal article 2023
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Warmink, Kelly (author), Rios, Jaqueline L. (author), Varderidou-Minasian, Suzy (author), Torres-Torrillas, Marta (author), van Valkengoed, Devin R. (author), Versteeg, Sabine (author), Eijkelkamp, Niels (author), Weinans, Harrie (author), Korthagen, Nicoline M. (author), Lorenowicz, Magdalena J. (author)Background: Mesenchymal stromal/stem cells (MSCs) and MSC-derived extracellular vesicles (MSC-EVs) hold promise as a disease modifying treatment in osteoarthritis (OA). Obesity, and its associated inflammation, contribute to OA development and metabolic OA represents a specific and significant group of the OA patient population. Given their...journal article 2023
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Saukko, Annina E.A. (author), Nykänen, Olli (author), Sarin, Jaakko K. (author), Nissi, Mikko J. (author), te Moller, Nikae C.R. (author), Weinans, Harrie (author), Mancini, Irina A.D. (author), Visser, Jetze (author), Brommer, Harold (author)To prevent the progression of posttraumatic osteoarthritis, assessment of cartilage composition is critical for effective treatment planning. Posttraumatic changes include proteoglycan (PG) loss and elevated water content. Quantitative dual-energy computed tomography (QDECT) provides a means to diagnose these changes. Here, we determine the...journal article 2021
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van Gemert, Y. (author), Kozijn, A. E. (author), Pouwer, M. G. (author), Kruisbergen, N. N.L. (author), van den Bosch, M. H.J. (author), Blom, A.B. (author), Pieterman, E. J. (author), Weinans, Harrie (author), Stoop, R. (author), Princen, H. M.G. (author), van Lent, P. L.E.M. (author)Objective: High systemic cholesterol levels have been associated with osteoarthritis (OA) development. Therefore, cholesterol lowering by statins has been suggested as a potential treatment for OA. We investigated whether therapeutic high-intensive cholesterol-lowering attenuated OA development in dyslipidemic APOE∗3Leiden.CETP mice. Methods:...journal article 2021
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Gielis, W. P. (author), Weinans, Harrie (author), Welsing, P. M.J. (author), van Spil, W. E. (author), Agricola, R. (author), Cootes, T. F. (author), de Jong, P. A. (author), Lindner, C. (author)Objective: To design an automated workflow for hip radiographs focused on joint shape and tests its prognostic value for future hip osteoarthritis. Design: We used baseline and 8-year follow-up data from 1,002 participants of the CHECK-study. The primary outcome was definite radiographic hip osteoarthritis (rHOA) (Kellgren–Lawrence grade ≥2...journal article 2020
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Kozijn, A. E. (author), Tartjiono, M. T. (author), Ravipati, S. (author), van der Ham, F. (author), Barrett, D. A. (author), Mastbergen, S. C. (author), Korthagen, N. M. (author), Lafeber, F. P.J.G. (author), Zuurmond, A. M. (author), Bobeldijk, I. (author), Weinans, Harrie (author), Stoop, R. (author)Objective: C-reactive protein (CRP) levels can be elevated in osteoarthritis (OA) patients. In addition to indicating systemic inflammation, it is suggested that CRP itself can play a role in OA development. Obesity and metabolic syndrome are important risk factors for OA and also induce elevated CRP levels. Here we evaluated in a human CRP ...journal article 2019
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Hirvasniemi, J. (author), Gielis, W. P. (author), Arbabi, S. (author), Agricola, R. (author), van Spil, W. E. (author), Arbabi, V. (author), Weinans, Harrie (author)Objective: To assess the ability of radiography-based bone texture variables in proximal femur and acetabulum to predict incident radiographic hip osteoarthritis (rHOA) over a 10 years period. Design: Pelvic radiographs from CHECK at baseline (987 hips) were analyzed for bone texture using fractal signature analysis (FSA) in proximal femur...journal article 2019
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de Visser, Huub M. (author), Sanchez, Christelle (author), Mastbergen, Simon C. (author), Lafeber, Floris P.J.G. (author), Henrotin, Yves E. (author), Weinans, Harrie (author)Objective: Fibulin-3 is a glycoprotein highly expressed in osteoarthritic cartilage and inhibits angiogenesis and chondrocyte differentiation. Recent studies have indicated that fibulin-3 has potential value as a biomarker in osteoarthritis. The aim of the present study is to examine the role of 3 fibulin-3 peptides (Fib3-1, Fib3-2, and Fib3...journal article 2019
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de Visser, H.M. (author), Korthagen, NM (author), Müller, C. (author), Ramakers, R.M. (author), Krijger, G.C. (author), Lafeber, F.P.J.G. (author), Beekman, F.J. (author), Mastbergen, S.C. (author), Weinans, Harrie (author)Objective. To evaluate the presence and localization of folate receptor expressing macrophages in the rat groove model of osteoarthritis and determine the suitability of a new folate conjugate with albumin-binding entity (cm09) for in vivo SPECT (single-photon emission computed tomography) analysis. Design. In male Wistar rats, local cartilage...journal article 2018