The response of human macrophages to 3D printed titanium antibacterial implants does not affect the osteogenic differentiation of hMSCs

Macrophage responses following the implantation of orthopaedic implants are essential for successful implant integration in the body, partly through intimate crosstalk with human marrow stromal cells (hMSCs) in the process of new bone formation. Additive manufacturing (AM) and plasma electrolytic oxidation (PEO) in the presence of silver...

Towards 3D Printed Osteoimmunomodulatory Surface Patterns

Osteoimmunomodulation (OIM) is a mechanism through which orthopedic biomaterials may modulate the function of immune cells to promote osteogenesis. OIM is considered a potentially effective way for improving osseointegration. The surface characteristics of orthopedic implants (e.g., topography, wettability, surface chemistry, and charge) can...

Osteoimmunomodulatory potential of 3D printed submicron patterns assessed in a direct co-culture model

Modulation of the immune response following the implantation of biomaterials can have beneficial effects on bone regeneration. This involves complex interactions between the inflammatory and osteogenic cells. Therefore, the study of cell-cell interactions using direct co-culture models integrated with biomaterials is of great interest. This...

Evaluation of the osteoimmunomodulatory properties of surface biofunctionalized 3D printed titanium bone implants

Background: Despite the considerable development of the field of orthopedic implants in the past century, complications including poor bone ingrowth and implant associated infection (IAI) persist to this day, causing a huge burden to millions of patients and the healthcare systems worldwide. Additive manufacturing (AM) and the subsequent surface...

Effects of surface-modified 3D printed titanium bone implants on human macrophages

Titanium orthopaedic biomaterials to replace degenerated joint surface, improve bone regeneration and fixation are studied and used worldwide. However, not always biomaterial implantation is successful, and the main causes of implant failure remain implant associated infections (IAI) and poor osseointegration. In the recent years, additive...