Multimodality imaging-based response prediction and monitoring to improve clinical management of gastrointestinal stromal tumours

Gastrointestinal stromal tumours (GISTs) are rare mesenchymal neoplasms with a worldwide incidence of one or two per 100,000. The tumours affect the entire gastrointestinal tract, but most commonly the stomach and small intestine. Neoadjuvant tyrosine kinase inhibitors (TKI) are administered in a selection of GIST patients to attain size...

PLIS: A metabolomic response monitor to a lifestyle intervention study in older adults

The response to lifestyle intervention studies is often heterogeneous, especially in older adults. Subtle responses that may represent a health gain for individuals are not always detected by classical health variables, stressing the need for novel biomarkers that detect intermediate changes in metabolic, inflammatory, and immunity-related...