Alzheimer’s disease, Aging and Centenarians

A remarkable accomplishment of human beings in recent centuries is the extension of their average lifespan, for example by improved living conditions. A downside of this achievement is that aging-related diseases, such as Alzheimer’s disease (AD), have risen, and as a consequence are impacting the lives of an increasing fraction of individuals....

Assessment of Predictive Genomic Biomarkers for Response to Cisplatin-based Neoadjuvant Chemotherapy in Bladder Cancer

Cisplatin-based neoadjuvant chemotherapy (NAC) followed by radical cystectomy is recommended for patients with muscle-invasive bladder cancer (MIBC). It has been shown that somatic deleterious mutations in ERCC2, gain-of-function mutations in ERBB2, and alterations in ATM, RB1, and FANCC are correlated with pathological response to NAC in...

Interpretable classification of tumours through multiple instance learning and somatic mutations

Next generation sequencing is brought into the clinic. Screening of disease associated genes will aid the diagnosis of disorders with a genetic component. The diagnosis of cancer is of particular interest due to its variety and prevalence. The obtained mutations provide clues about underlying biological properties that could be used for...