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Zwartveld, Stef (author)Subjective tinnitus is a sensation of sound without an external source. There is no clear understanding of the cause and pathology of tinnitus.<br/><br/>Literature suggests a combination of deafferentation of the tonotopic map , the Bayesian brain model, and the triple mode network, creating one combined hypothesis for tinnitus pathology. Based...master thesis 2024
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Li, J. (author)Around 10% of the population will have to go through a catheterization procedure for the treatment of a cardiovascular disease at a certain stage of their lives. During such a procedure, smart catheters will be the "eyes and ears" of the surgeons, significantly improving the diagnosis and treatment. However, there have been very limited...doctoral thesis 2024
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van Lith, Niels (author)The development of neural prostheses, especially those directly targeting the brain, requires extensive research and modelling before clinical trials can be performed. Currently, the resolution of artificial vision is not sufficient for everyday tasks. By studying the expected spatial extent of stimulation, we aim to provide insights to...master thesis 2024
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Shokri, M. (author), Gogliettino, Alex R. (author), Hottowy, Paweł (author), Sher, Alexander (author), Litke, Alan M. (author), Chichilnisky, E. J. (author), Pequito, Sérgio (author), Muratore, D.G. (author)Objective. Bi-directional electronic neural interfaces, capable of both electrical recording and stimulation, communicate with the nervous system to permit precise calibration of electrical inputs by capturing the evoked neural responses. However, one significant challenge is that stimulation artifacts often mask the actual neural signals. To...journal article 2024
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Luijten, Janne (author)<b>Introduction</b><br/>Chronic pain is an increasing problem in terms of prevalence and disease-related costs. Due to its complexity, it is difficult to treat. Spinal cord stimulation (SCS) is a neurostimulation therapy with a relatively good success rate for patients with severe, intractable chronic pain. The mechanisms of action (MOAs) of SCS...master thesis 2023
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Zwinkels, Anouk (author)<b>Introduction</b>: Deep brain stimulation (DBS) is an important therapeutic option for various neurological diseases. For certain indications the optimal target cannot be identified on structural magnetic resonance imaging (MRI), but can be visualized with tractography. A recent improvement for clinical practice is the probabilistic...master thesis 2023
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xue, chunyan (author)Vagus nerve stimulation serves as an approach to manage drug-resistant epilepsy. Focused ultrasound stands out as a unique tool, offering a non-invasive modality for VNS. With its excellent depth of penetration and sub-millimeter focusing capabilities in soft tissue, ultrasound allows for precise targeting of the vagus nerve without the need for...master thesis 2023
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Muller, Marjolein (author)Introduction: Over the past two decades deep brain stimulation (DBS) has emerged as an important therapeutic option for Parkinson’s disease (PD). However, the current DBS programming method, monopolar review (MPR), is time-consuming, requires highly trained personnel and causes discomfort for patients. This study aimed to predict the optimal...master thesis 2023
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Toitos, Christos (author)Electrical stimulation has emerged as a promising therapeutic modality for the treatment of various neurological disorders such as Parkinson's disease, chronic pain, epilepsy, and depression. In addition, recent studies have provided evidence supporting the effectiveness of electrical stimulation as a treatment option for patients with chronic...master thesis 2023
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Scholtes, Mathilde (author)Introduction: The positioning of spinal cord stimulation (SCS) leads in the epidural space to deliver therapy for chronic pain currently relies on intraoperative feedback from the patient. This feedback is not always reliable due to sedation, discomfort, and prone positioning of the patient. Excluding the need for patient feedback by performing...master thesis 2023
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Rice, Samantha (author)Numerous advancements have been made in transparent electrode technologies that can complement optogenetics and imaging modalities. However, several obstacles restrict the design and material of electrode devices, including the required flexibility, transparency, low impedance, high charge storage<br/>capacity (CSC), and high charge injection...master thesis 2023
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Luo, W. (author), Kottsova, A. (author), Vardon, P.J. (author), Dieudonné, A.A.M. (author), Brehme, M. (author)In geothermal projects, reinjection of produced water has been widely applied for disposing wastewater, supplying heat exchange media and maintaining reservoir pressure. Accordingly, it is a key process for environmental and well performance assessment, which partly controls the success of projects. However, the injectivity, a measure of how...review 2023
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Jahanmard, F. (author), Khodaei, A. (author), Flapper, Jasper (author), Dogan, O. (author), Roohi, K. (author), Taheri, P. (author), Weinans, Harrie (author), Storm, G. (author), Croes, M. (author), Mastrobattista, E. (author), Amin Yavari, S. (author)Despite being the most widely used biomaterials in orthopedic surgery, metallic implants do not induce new bone growth because they are bioinert. Surface biofunctionalization of implants with immunomodulatory mediators is a recent approach to promote osteogenic factors that facilitate bone regeneration. Liposomes (Lip) can be used as a low-cost,...journal article 2023
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Laursen, Kjeld (author), Zamani, M. (author), Rezaeiyan, Y. (author), Hosseini, Seyedsina (author), Mondal, Tanmay (author), Corbett, Brian (author), Ouagazzal, Abdel Mouttalib (author), Amalric, Marianne (author), Moradi, Farshad (author)This brief presents an ultrasonically powered micro-system for deep tissue optogenetic stimulation. The developed system is composed of a Base for Powering and Controlling (BPC) and an implantable Dust for optogenetics and drug delivery. The Dust consists of a piezoelectric crystal, a rectifier chip, and a micro-scale custom-designed light...journal article 2023
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Späth, Jana M. (author), Kolovou Kouri, K. (author), Holzapfel, L.F.M. (author), Thewes, Roland (author), Giagka, Vasiliki (author)Safety is a critical consideration when designing an electrical neural stimulator, given the direct contact with neural tissue. This paper presents the design of a charge balancing system suitable for frequencies up to the kilohertz domain, to be used as an add-on system for stimulators over a wide range of frequencies, also covering nerve...conference paper 2023
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Rashidi, A. (author), Rivandi, H. (author), Grubor, M. (author), Agostinho, Andre (author), Sadio, Valter (author), Santos, Marcelino (author), Serdijn, W.A. (author), Giagka, Vasiliki (author)This paper presents a novel multi-channel stimulation backend with a multi-bit delta-sigma control loop, which enables precise adjustment of the stimulation current through modulation of the supply voltage. This minimizes the overhead voltage of series circuitry to the stimulation load and avoids the associated energy loss. Additionally, to...conference paper 2023
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Varkevisser, F. (author), Lopes Marta da Costa, T.M. (author), Serdijn, W.A. (author)Developing neuroprosthetic bioelectronic devices requires wirelessly-powered implantable stimulator systems with hundreds to thousands of output channels. Power efficiency optimization is crucial for scaling up the number of output channels. Current-mode electrical stimulation is favored for safety but is power-inefficient in conventional...conference paper 2023
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Reinders, Laurien (author)<b>Introduction</b>: Spinal Cord Stimulation (SCS) is a successful last-resort treatment for chronic pain patients, although its exact mechanisms of action (MOAs) still need to be unraveled. The MOAs of SCS partly rely on spinal mechanisms (gate control theory) and supraspinal mechanisms likely play a role as well. Pain processing involves a...master thesis 2022
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van Lange, Eline (author)Background: Complex regional pain syndrome (CRPS) is a clinical disorder characterized by continuous, disproportionate pain and sensory, vasomotor, sudomotor and motor trophic changes. CRPS patients have a heterogeneous clinical picture caused by multiple underlying pathophysiology mechanisms including inflammation, vasomotor disturbances and...master thesis 2022
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Schreuder, Anniek (author)Over the years, the marine contracting sector has faced many challenges surrounding safety, the economic fluctuations because of the oil crisis and now tackling the sustainability challenge. Years of experience in the offshore industry, a heavy industry that contributes significantly to the climate crisis through its environmental impact, is...master thesis 2022