Personalisation of Plantarflexor Musculotendon Model Parameters in Children with Cerebral Palsy

Neuromusculoskeletal models can be used to evaluate aberrant muscle function in cerebral palsy (CP), for example by estimating muscle and joint contact forces during gait. However, to be accurate, models should include representative musculotendon parameters. We aimed to estimate personalised parameters that capture the mechanical behaviour...

Personalized local SAR prediction for parallel transmit neuroimaging at 7T from a single T1-weighted dataset

Purpose: Parallel RF transmission (PTx) is one of the key technologies enabling high quality imaging at ultra-high fields (≥7T). Compliance with regulatory limits on the local specific absorption rate (SAR) typically involves over-conservative safety margins to account for intersubject variability, which negatively affect the utilization of...

Opensim upper-extremity modelling: subject-specific scaling- and validation tools

Muscle-driven simulations performed with a musculoskeletal model of the human upper-extremity need to include closed-loop kinematics to capture the limb's full mobility and model the actions of thoracoscapular muscles. On the OpenSim platform, a single upper-extremity model with closed-loop kinematics is available: the thoracoscapular shoulder...

Calf muscle model parameters in children with cerebral palsy compared to typically developing children

Background: In children with cerebral palsy(CP), muscle-tendon structures are altered. While interventions exist to treataltered structures, the selection of the most suitable treatment is verycomplex with highly variable outcomes. Musculoskeletal models have thepotential to support clinical decision making. However, a known...

Evaluation of Musculoskeletal Model Personalization for Gait Analysis of Children with Cerebral Palsy

Musculoskeletal modeling and simulation has become a prominent tool in clinical gait analysis with the ability to provide insight into the underlying mechanisms of human movement. However, generic cadaver-based models have been shown to poorly reflect live subjects, especially those with pathologies such as cerebral palsy (CP). The main purpose...