Engineered biochemical cues of regenerative biomaterials to enhance endogenous stem/progenitor cells (ESPCs)-mediated articular cartilage repair

As a highly specialized shock-absorbing connective tissue, articular cartilage (AC) has very limited self-repair capacity after traumatic injuries, posing a heavy socioeconomic burden. Common clinical therapies for small- to medium-size focal AC defects are well-developed endogenous repair and cell-based strategies, including microfracture,...

Functionalized Hydrogels for Articular Cartilage Tissue Engineering

Articular cartilage (AC) is an avascular and flexible connective tissue located on the bone surface in the diarthrodial joints. AC defects are common in the knees of young and physically active individuals. Because of the lack of suitable tissue-engineered artificial matrices, current therapies for AC defects, especially full-thickness AC...

Denoising controlled-source electromagnetic data using least-squares inversion

Strong noise is one of the toughest problems in the controlled-source electromagnetic (CSEM) method, which highly affects the quality of recorded data. The three main types of noise existing in CSEM data are periodic noise, Gaussian white noise, and nonperiodic noise, among which the nonperiodic noise is thought to be the most difficult to...