This paper presents the computational challenge on topological deep learning that was hosted within the ICML 2023 Workshop on Topology and Geometry in Machine Learning. The competition asked participants to provide open-source implementations of topological neural networks from the literature by contributing to the python packages TopoNetX (data processing) and TopoModelX (deep learning). The challenge attracted twenty-eight qualifying submissions in its two month duration. This paper describes the design of the challenge and summarizes its main findings.@en

This paper optimizes the MNEMOSENE architecture, a compute-in-memory (CiM) tile design integrating computation and storage for increased efficiency. We identify and address bottlenecks in the Row Data (RD) buffer that cause losses in performance. Our proposed approach includes mitigating these buffering bottlenecks and extending MNEMOSENE’s single-tile design to a multi-tile configuration for improved parallel processing. The proposal is validated through comprehensive analyses exploring the mapping of diverse neural networks evaluated on CiM crossbar arrays based on NVM technologies. These proposed enhancements lead up to 55% reduction in execution time compared to the original single-tile architecture for any general matrix multiplication (GEMM) operation. Our evaluation shows that while ReRAM and PCM offer notable energy advantages, their integration with scaled CMOS is limited, which leads to VGSOT-MRAM emerging as a promising alternative due to its good balance between energy efficiency and superior integration capabilities. The VGSOT-MRAM crossbar arrays provide 12×,49×, and 346× more energy efficiency than PCM, ReRAM, and STT-MRAM ones, respectively. It translates, on average for the considered workload, in 1.5×,3×, and 14.5× better energy efficiency of the entire system.@en

Introduction Both late-onset Alzheimer’s disease (AD) and ageing have a strong genetic component. In each case, many associated variants have been discovered, but how much missing heritability remains to be discovered is debated. Variability in the estimation of SNP-based heritability could explain the differences in reported heritability. Methods We compute heritability in five large independent cohorts (N = 7,396, 1,566, 803, 12,528 and 3,963) to determine whether a consensus for the AD heritability estimate can be reached. These cohorts vary by sample size, age of cases and controls and phenotype definition. We compute heritability a) for all SNPs, b) excluding APOE region, c) excluding both APOE and genome-wide association study hit regions, and d) SNPs overlapping a microglia gene-set. Results SNP-based heritability of late onset Alzheimer’s disease is between 38 and 66% when age and genetic disease architecture are correctly accounted for. The heritability estimates decrease by 12% [SD = 8%] on average when the APOE region is excluded and an additional 1% [SD = 3%] when genome-wide significant regions were removed. A microglia gene-set explains 69–84% of our estimates of SNP-based heritability using only 3% of total SNPs in all cohorts. Conclusion The heritability of neurodegenerative disorders cannot be represented as a single number, because it is dependent on the ages of cases and controls. Genome-wide association studies pick up a large proportion of total AD heritability when age and genetic architecture are correctly accounted for. Around 13% of SNP-based heritability can be explained by known genetic loci and the remaining heritability likely resides around microglial related genes.@en