Design solutions bases on Evidence Based Design (EBD) principles vary due to the context and organizational aspects of hospitals. This paper explains how EBD principles were included during the design process of an academic hospital, including design guidelines that were developed with a representative group of key stakeholders from the organization. The hospital comprises several buildings on a campus, that also includes several university buildings. Some of the hospital buildings are connected through “the main axe.” The principles were applied on different scales in the design of a new main building and transformation of an existing building and the main axe, connecting other buildings. Specific design solutions for daylight access, connection to nature, art, privacy, and interaction are discussed.@en