Unconventional reservoir resources are important to supplement energy consumption and maintain the balance of supply and demand in the oil and gas market. However, due to the complex geological conditions, it is a significant challenge to develop unconventional reservoirs efficiently and economically. At present, unconventional reservoirs are extensively studied, covering a wide range of areas, with special attention to the multiscale characterization of pore structures and fracture networks, description of complex fluid transport mechanisms, mathematical modeling of flow properties, and coupled analysis with multiphysics fields. This work briefly describes the multiscale and multiphysics influences on fluids in unconventional reservoirs, and the modeling and simulation work conducted to analyze them, with the aim to provide some theoretical basis for enhanced recovery from these geo-energy resources. The present article also aims to enhance the community’s knowledge of other potential utilizations associated with some unconventional reservoirs, specially related to environmentally-driven projects, including permanent greenhouse gas storage and cyclic underground energy storage.