This thesis explores how perceptions within Global North–South research collaborations can inform strategies to promote equity in open science (OS) integration at TU Delft. While the university has positioned itself as a leader in open science, there remains a gap between institutional policy and the lived experiences of researchers. Many researchers, even those aligned with the values of open science, lack a clear framework to meaningfully engage with its principles, particularly in relation to equity. Through a framework combining Sabina Leonelli's Philosophy of Open Science and UNESCO’s Recommendation on Open Science, along with semi-structured interviews with scientists associated with the TU Delft Global Initiative, this research highlights how multidirectional dialogue and reflection can reshape perceptions and practices. The research revealed a shared desire for spaces that promote critical engagement, capacity-building, and mutual learning, as seen in initiatives like Global Initiative Luncheons and GROW PhD events. However, while TU Delft has made progress in accessibility, there is a significant gap in addressing the dominance of the Global North in scientific knowledge production. Many researchers remain unaware of the broader implications of open science, and the university's 2024-2028 Strategic Plan lacks clear initiatives to support inclusive, multidirectional exchanges, particularly with marginalized communities. The findings emphasize the need for the continuation of current efforts and the fostering of more communities to amplify the contributions of Global South researchers and promote equitable collaborations. By centering the voices of participating scientists, this thesis argues that the process of research—how we listen, reflect, and collaborate—can itself be an act of open science. In doing so, it invites a broader understanding of what it means to do science in service of equity.