In this perspective article, we celebrate the accomplishments of female-led research groups in biocatalysis. Through this initiative, we aim to showcase the breadth and excellence of women's research and increase their visibility within the catalysis community. The authors wish to emphasize that this perspective article represents only a small selection of the extraordinary women who have shaped the field of biocatalysis over time. Among them are scientists who have directly or significantly influenced and inspired the authors’ scientific journeys.