The prospect of cement and concrete technologies depends on more in depth understanding of cement hydration reactions. Hydration reaction models simulate the development of the microstructures that can finally be used to estimate the cement based material properties that influence performance and service life. In this paper the multicomponent model of portland cement hydration reactions is implemented within the original Hymostruc model. The reaction kinetics of the four principal clinker minerals, C3S, C2S, C3A, C4AF, are coupled to the microstructure development. The nature of ettringite transformation to monosulfate is described by sequential chemical reactions of aluminate bearing clinker minerals. The calculated results of the model are shown and compared with systematic literature experimental results investigating the hydration of two different ordinary portland cements. Good agreement was obtained for the component fractional evolution and released heat during hydration.