We investigate natural convection driven by a horizontal temperature gradient and a vertical concentration gradient in fluid-filled enclosures with obstructions inside it. Within the domain, nine adiabatic and impermeable cylinders are placed, occupying 30% of the domain volume. The Boussinesq approximation is used to account for density variations within the fluid and the flow is fully resolved. The solutal Rayleigh number has been fixed at Ra_C=10⁶ and the Prandtl number at Pr=5.4. The Lewis number has been varied in the range of 1 ≤ Le ≤ 100 and the buoyancy ratio in the range of 0.1 ≤ |N| ≤ 10. The rate of heat and mass transfer are compared to those found in single-scalar natural convection, i.e solely thermal or concentration driven convection. Besides, the obtained heat and mass transfer rate in the cylinder-packed enclosure have been compared to those found in a fluid-only domain. We observe that the addition of a destabilizing concentration gradient to a side-heated enclosure results in heat transfer enhancement, which decreases with Lewis number and thermal Rayleigh number. Similarly, the temperature gradient increases the mass transfer, especially at high Lewis numbers and lower concentration buoyancy force over its thermal counterpart. Although the presence of the cylindrical obstacles reduced the flow velocity, the mass transfer was enhanced at lower buoyancy ratio.