Artificial Intelligence (AI) is transforming every aspect of modern society. It demonstrates a high potential to contribute to more flexible operations of safety-critical network infrastructures under deep transformation to tackle global challenges, such as climate change, energy transition, efficiency, and digital transformation, including increasing infrastructure resilience to natural and human-made hazards. The widespread adoption of AI creates the conditions for a new and inevitable interaction between humans and AI-based decision systems. In such a scenario, creating an ecosystem in which humans and AI interact healthily, where the roles and positions of both actors are well-defined, is a critical challenge for research and industry in the coming years. This perspective article outlines the challenges and requirements for effective human-AI interaction by taking an interdisciplinary point of view that merges computer science, decision-making sciences, psychological constructs, and industrial practices. The work focuses on three emblematic safety-critical scenarios from two different domains: energy (power grids) and mobility (railway networks and air traffic management).

The interaction between humans and AI in safety-critical systems presents a unique set of challenges that remain partially addressed by existing frameworks. These challenges stem from the complex interplay of requirements for transparency, trust, and explainability, coupled with the necessity for robust and safe decision-making. A framework that holistically integrates human and AI capabilities while addressing these concerns is notably required, bridging the critical gaps in designing, deploying, and maintaining safe and effective systems. This paper proposes a holistic conceptual framework for critical infrastructures by adopting an interdisciplinary approach. It integrates traditionally distinct fields such as mathematics, decision theory, computer science, philosophy, psychology, and cognitive engineering and draws on specialized engineering domains, particularly energy, mobility, and aeronautics. Its flexibility is further demonstrated through a case study on power grid management.