The global transition towards renewable energy sources necessitates advancements in energy storage technology to address the intermittency of renewable sources like solar and wind. Redox flow batteries, such as the zinc-air redox flow battery, offer promising solutions with flexible storage capacity and long cycle life. However, identifying a suitable redox mediator for the air side remains a significant challenge. perylene-derivatives, known for their electrochemical activity, recyclability, and redox stability, are potential candidates for this role. This research evaluates various perylene-derivatives for their electrochemical activity as mediators in zinc-air redox flow batteries, focusing on redox potential, solubility, and stability. While the study demonstrated that modifying substitution groups on the perylene core could achieve the desired reduction potential, achieving high solubility remains challenging. Therefor optimization of substitution groups is required to develop perylene-derivatives that meet the necessary criteria. Overall, although more research is required to find effective redox mediators, perylene-derivatives show significant potential for zinc-air redox flow batteries.