With the construction of high-speed railway in 2007, and the establishment of five direct controlled municipalities along the west coast of Taiwan in 2010, theses changes offer opportunities to redirect and redefine the role of Tainan and its spatial strategy. The project first discuss the possible morphology for south region. With serious analysis to tackle on the possible relationship between Tainan and Kaohsiung thus to re-identify the role of Tainan city. The analysis and the references made me to decide to use culture-led urban regeneration as the strategy to revitalize Tainan’s potentiality, solve city’s social and economic problems. At the same time to strengthen the complimentary relationship between Tainan and Kaohsiung. First, Tainan city scale strategy will be presented together with serious infrastructure planning. By achieving multimodal transport city to prepare a better condition for the following intervention. When step into the design parameter, tackle on neighborhood scale and discuss the issue of what kind of regeneration can revitalize local culture resources and attract the clustering of creative cluster.