Wall shear rate (WSR), a key marker of vascular health, is useful for cardiovascular risk assessment. Traditionally, its non-invasive evaluation via ultrasound relies on longitudinal imaging of the artery, a method that can be restrictive for comprehensive hemodynamic monitoring. Here a bi-plane ultrasound method using a 2D sparse array for fast, cross-sectional WSR estimation is presented. The technique provides 12 simultaneous, angularly distributed WSR estimates per frame, overcoming limitations of conventional methods and avoiding the hardware complexity of full 3D imaging. Phantom experiments were conducted at different depths with good accuracy (bias<16%) and repeatability (<21%).

Objective: The aim of this study was to assess the feasibility and imaging options of contrast-enhanced volumetric ultrasound kidney vasculature imaging in a porcine model using a prototype sparse spiral array. Methods: Transcutaneous freehand in vivo imaging of two healthy porcine kidneys was performed according to three protocols with different microbubble concentrations and transmission sequences. Combining high-frame-rate transmission sequences with our previously described spatial coherence beamformer, we determined the ability to produce detailed volumetric images of the vasculature. We also determined power, color and spectral Doppler, as well as super-resolved microvasculature in a volume. The results were compared against a clinical 2-D ultrasound machine. Results: Three-dimensional visualization of the kidney vasculature structure and blood flow was possible with our method. Good structural agreement was found between the visualized vasculature structure and the 2-D reference. Microvasculature patterns in the kidney cortex were visible with super-resolution processing. Blood flow velocity estimations were within a physiological range and pattern, also in agreement with the 2-D reference results. Conclusion: Volumetric imaging of the kidney vasculature was possible using a prototype sparse spiral array. Reliable structural and temporal information could be extracted from these imaging results.

Two-dimensional (2-D) arrays offer volumetric imaging capabilities without the need for probe translation or rotation. A sparse array with elements seeded in a tapering spiral pattern enables one-to-one connection to an ultrasound machine, thus allowing flexible transmission and reception strategies. To test the concept of sparse spiral array imaging, we have designed, realized, and characterized two prototype probes designed at 2.5-MHz low-frequency (LF) and 5-MHz high-frequency (HF) center frequencies. Both probes share the same electronic design, based on piezoelectric ceramics and rapid prototyping with printed circuit board substrates to wire the elements to external connectors. Different center frequencies were achieved by adjusting the piezoelectric layer thickness. The LF and HF prototype probes had 88% and 95% of working elements, producing peak pressures of 21 and 96 kPa/V when focused at 5 and 3 cm, respectively. The one-way -3-dB bandwidths were 26% and 32%. These results, together with experimental tests on tissue-mimicking phantoms, show that the probes are viable for volumetric imaging.

Transducer arrays for 3D imaging are characterized by elements distributed over a 2D surface. The dimensions of each element are typically one half-wavelength in both x- and y-directions. Such small elements inherently have a high electrical impedance. When the elements are connected to a probe cable, the high cable capacitance decimates the delivered voltage and results in a poor Signal to Noise Ratio (SNR). This may have dramatic effects, especially in sparse arrays, where a small number of elements contributes to the beamformed signal. In this paper we demonstrate that the use of in-probe preamplifiers in a sparse PZT probe is valuable to significantly increase the SNR.