During daily operations, relief agencies such as police, fire brigade and medical services manage information in accordance with their respective processes and organization structure. When disaster strikes, the ad-hoc combinations of such hierarchy based information systems fail to assure high information quality (IQ) and system quality (SQ) for relief workers. Disaster such as 9/11, Katrina and the Polderbaan-crash have taught us that poor IQ and SQ significantly hamper disaster response efforts and can be lethal for relief workers and citizens. Drawing on empirical data (field studies) and pathways in ‘state of the art’ theories, this dissertation presents ten design principles for assuring IQ and SQ in public safety networks. These principles are the cornerstones of a design theory coined as ‘Netcentric Information Orchestration’ and are meant to guide information system architects, practitioners, software vendors and policy makers in the (re)design of information systems for disaster response. We evaluated the design principles on their technical feasibility (using prototyping) and on their ability to assure IQ and SQ for relief workers (using quasi-experimental gaming-simulation). Findings indicate that the proposed design principles assure higher levels for most IQ and SQ dimensions.