Background: An increasing number of wearables are capable of measuring electrocardiograms (ECGs), which may help in early detection of atrial fibrillation (AF). Therefore, many studies focus on automated detection of AF in ECGs. A major obstacle is the required amount of manually labelled data. This study aimed to provide an efficient and reliable method to train a classifier for AF detection using large datasets of real-life ECGs. Method: Human-controlled semi-supervised learning was applied, consisting of two phases: the pre-training phase and the semi-automated training phase. During pre-training, an initial classifier was trained, which was used to predict the classes of new ECG segments in the semi-automated training phase. Based on the degree of certainty, segments were added to the training dataset automatically or after human validation. Thereafter, the classifier was retrained and this procedure was repeated. To test the model performance, a real-life telemetry dataset containing 3,846,564 30-s ECG segments of hospitalized patients (n = 476) and the CinC Challenge 2017 database were used. Results: After pre-training, the average F1-score on a hidden testing dataset was 89.0%. Furthermore, after the pre-training phase 68.0% of all segments in the hidden test set could be classified with an estimated probability of successful classification of 99%, providing an F1-score of 97.9% for these segments. During the semi-automated training phase, this F1-score showed little variation (97.3%–97.9% in the hidden test set), whilst the number of segments which could be automatically classified increased from 68.0% to 75.8% due to the enhanced training dataset. At the same time, the overall F1-score increased from 89.0% to 91.4%. Conclusions: Human-validated semi-supervised learning makes training a classifier more time efficient without compromising on accuracy, hence this method might be valuable in the automated detection of AF in real-life ECGs.

Aims: Automated detection of atrial fibrillation (AF) in continuous rhythm registrations is essential in order to prevent complications and optimize treatment of AF. Many algorithms have been developed to detect AF in surface electrocardiograms (ECGs) during the past few years. The aim of this systematic review is to gain more insight into these available classification methods by discussing previously used digital biomarkers and algorithms and make recommendations for future research. Methods: On the 14^th of September 2020, the PubMed database was searched for articles focusing on algorithms for AF detection in ECGs using the MeSH terms Atrial Fibrillation, Electrocardiography and Algorithms. Articles which solely focused on differentiation of types of rhythm disorders or prediction of AF termination were excluded. Results: The search resulted in 451 articles, of which 130 remained after full-text screening. Not only did the amount of research on methods for AF detection increase over the past years, but a trend towards more complex classification methods is observed. Furthermore, three different types of features can be distinguished: atrial features, ventricular features, and signal features. Although AF is an atrial disease, only 22% of the described methods use atrial features. Conclusion: More and more studies focus on improving accuracy of classification methods for AF in ECGs. As a result, algorithms become increasingly complex and less well interpretable. Only a few studies focus on detecting atrial activity in the ECG. Developing innovative methods focusing on detection of atrial activity might provide accurate classifiers without compromising on transparency.