A high fidelity aircraft simulation model, reconstructed using the Digital Flight Data Recorder (DFDR) of the 1992 Amsterdam Bijlmermeer aircraft accident (Flight 1862), has been used to evaluate a new Fault-Tolerant Flight Control Algorithm in an online piloted evaluation. This paper focuses on the piloted simulator evaluation results. Reconfiguring control is implemented by making use of Adaptive Nonlinear Dynamic Inversion (ANDI) for manual fly by wire control. After discussing the modular adaptive controller setup, the experiment is described for a piloted simulator evaluation of this innovative recon- figurable control algorithm applied to a damaged civil transport aircraft. The evaluation scenario, measurements and experimental design, as well as the real-time implementation are described. Finally, reconfiguration test results are shown for damaged aircraft models including component as well as structural failures. The evaluation shows that the FTFC algorithm is able to restore conventional control strategies after the aircraft configuration has changed dramatically due to these severe failures. The algorithm supports the pilot after a failure by lowering workload and allowing a safe return to the airport. For most failures, the handling qualities are shown to degrade less with a failure than the baseline classical control system does.