Phase change materials (PCMs) with considerable energy storage density show promise for building cooling performance enhancements, but the cooling performance is highly dependent on novel PCM-integrated forms and intelligent control strategies. This chapter provides a state-of-the-art review of novel PCM-based strategies for building cooling performance enhancements. The strategies investigated include PCM-integrated forms (such as distributed and coupled systems) and combined strategies (such as high-reflective coatings, radiative cooling walls, and hybrid ventilation). Heat transfer mechanisms for both distributed and coupled systems have been characterized to provide an in-depth understanding. Solutions for system performance enhancement of novel PCM-based cooling systems have been comprehensively presented. Future studies and prospects have been demonstrated as avenues for future research. This study presents a systematic overview of novel PCM-based strategies for cooling performance enhancement, together with technical challenges of the widespread applications. Research results are critical for the application and promotion of novel PCM-based cooling strategies in buildings.