Due to low activity or long mineralization time, traditional mineral agents for self-healing concrete generally need a long time to achieve a desired repair efficiency. Inspired by epoxy resin AB glue which can consolidate in a short time when mixing the two components together, a novel type of fast-responsive capsules based on two soluble components was designed for self-healing concrete. Component A (sodium carbonate) and component B (calcium acetate) were encapsulated in two different groups of capsules, respectively, coated with three layers consisting of epoxy resin and fine sands to achieve superior waterproof and alkali resistance properties. After rupture of the capsules, the rapid response with respect to core material dissolution and precipitation can be realized in presence of water, by which the cracks below 200 μm can be healed in 3 days. Super absorbent resin (SAP) embedded in the capsules could expand in contact with water, and further improve the self-healing efficiency of the capsules by blocking the crack.