Twisted steel bars are often used to strengthen masonry buildings and, in particular, to improve the transverse connection between different structural elements. The performance of the retrofitted structure depends on several parameters such as the mechanical properties of the base material (masonry), the bar diameter, the pre-drilled hole diameter. The paper presents the numerical assessment of the tensile behavior of twisted stainless-steel bars installed in brickwork masonry. Nonlinear numerical models in Abaqus software were developed and validated on the basis of experimental results, considering different bar diameters (8, 10, 12 mm). A parametric study was conducted to examine the factors that could influence the performance, namely the embedment depth, the pre-hole diameter, and the mechanical properties of the base material. The outcomes reveal the sensitivity of the twisted bars to the aforementioned parameters. In particular, the twisted bars exhibited a higher capacity in stiffer base materials, with longer embedment and smaller pre-drilled hole. However, none of the above parameters proportionally affect the ultimate strength, but lead to a limited improvement in the ultimate capacity (up to 40% in the considered range).