This research presents a simulation framework that helps improve ECD operations and system dynamics understanding. By applying the approach to a real-world case, the MedRepair Smirnoffweg depot, this study not only contributed to the academic understanding of ECD operations, but also supported informed decision-making for improving depot efficiency. By developing a generic model and applying the theories discussed, this research provided valuable support for planning both existing and new depot facilities with similar operational characteristics and challenges. Adaptive layout configurations and stacking strategies help depots respond better to seasonal demand fluctuations and varying truck interarrival patterns. By testing different designs in realistic scenarios, improvements can be made in equipment use, driving distances and bottleneck control within the system.