Interface engineering is a simple and effective strategy for improving the photovoltaic performance and stability of perovskite solar cells (PSCs). Herein, an interface co-modification strategy is proposed, using [6,6]-phenyl-C61-butyric acid methyl ester (PCBM) and 2-fluoro-1,4-phenylenediammonium iodide (2FPPD) to modify the electron transport layer (ETL)/perovskite (PVK) and the PVK/hole transport layer (HTL) interfaces, respectively. A series of characterizations demonstrate that the PCBM&2FPPD interface co-modification strategy effectively enhances the extraction and transport efficiency of carriers at the interface, passivates surface defects, inhibits the nonradiative recombination of carriers, and simultaneously inhibits ion migration. Moreover, this strategy improves the crystallinity and surface hydrophobicity of PVK and optimizes the energy level alignment of PSCs. As a result, all photovoltaic parameters are improved after optimization, where the power conversion efficiency (PCE) of PSCs has increased from 17.01% to 18.36%. Meanwhile, the optimized PSCs show excellent environmental stability, which can be stably stored in air (RH = 10-20%) for about 800 h.