Epitaxial YBa2Cu3O7-δ films nucleate in c-axis oriented single-crystalline islands. The surface of the single-crystalline SrTiO3 substrates exhibit steps of one third of the YBa2Cu3O7-δ c-axis. These steps generate a mismatch in the island boundaries between the CuO2 superconducting blocks. We show that these defect regions are strong candidates for being the pinning centers responsible for the large critical currents observed in Laser Ablated and Sputtered thin films.@en