The Jupiter Icy Moons Explorer (JUICE) is a European Space Agency mission to explore Jupiter and its three icy Galilean moons: Europa, Ganymede, and Callisto. Numerous JUICE investigations concern the magnetised space environments containing low-density populations of charged particles that surround each of these bodies. In the case of both Jupiter and Ganymede, the magnetic field generated internally produces a surrounding volume of space known as a magnetosphere. All these regions are natural laboratories where we can test and further our understanding of how such systems work, and improved knowledge of the environments around the moons of interest is important for probing sub-surface oceans that may be habitable. Here we review the magnetosphere and plasma science that will be enabled by JUICE from arrival at Jupiter in July 2031. We focus on the specific topics where the mission will push forward the boundaries of our understanding through a combination of the spacecraft trajectory through the system and the measurements that will be made by its suite of scientific instruments. Advances during the initial orbits around Jupiter will include construction of a comprehensive picture of the poorly understood region of Jupiter’s magnetosphere where rigid plasma rotation with the planet breaks down, and new perspectives on how Jupiter’s magnetosphere interacts with both Europa and Callisto. The later orbits around Ganymede will dramatically improve knowledge of this moon’s smaller magnetosphere embedded within the larger magnetosphere of Jupiter. We conclude by outlining the high-level operational strategy that will support this broad science return.

We investigate the feasibility of detecting water molecules (H₂O) and water ions (H₂O⁺) from the Europa plumes from a flyby mission. A Monte Carlo particle tracing method is used to simulate the trajectories of neutral particles under the influence of Europa's gravity field and ionized particles under the influence of Jupiter's magnetic field and the convectional electric field. As an example mission case we investigate the detection of neutral and ionized molecules using the Particle Environment Package (PEP), which is part of the scientific payload of the future JUpiter ICy moon Explorer mission (JUICE). We consider plumes that have a mass flux that is three orders of magnitude lower than what has been inferred from recent Hubble observations (Roth et al., 2014a). We demonstrate that the in-situ detection of H₂O and H₂O⁺ from these low mass flux plumes is possible by the instruments with large margins with respect to background and instrument noise. The signal to noise ratio for neutrals is up to ∼5700 and ∼33 for ions. We also show that the geometry of the plume source, either a point source or 1000km-long crack, does not influence the density distributions, and thus, their detectability. Furthermore, we discuss how to separate the plume-originating H₂O and H₂O⁺ from exospheric H₂O and H₂O⁺. The separation depends strongly on knowledge of the density distribution of Europa's exosphere.