In this thesis measurements on single and coupled Josephson persistent current qubits are presented. The Josephson persistent current qubit consists of a superconducting loop intersected by three Josephson junctions. When half a flux quantum is applied to the loop this system acts as a quantum two state system. The two states are associated with a clock or anti clockwise current flowing in the loop and can be measured using a SQUID magnetometer. The research presented in this thesis aimed at achieving coupling between two Josephson persistent current qubits and to show conditional gate operations in such a coupled qubit system. Also it was tried to improve the coherence properties of a single qubit by using a gradiometer type configuration to minimize influence from fluxnoise which would cause a disturbance of the energy bias of the qubit system. The basic principles of the Josephson persistent current qubit are discussed, as well as design criteria to minimize decoherence due to the environment seen by the squid or microwave lines. Spectroscopy measurements have been performed on coupled qubit systems mapping out the energy level structure of these systems. For two coupled qubits the origin and magnitude of the coupling J is derived for coupling via the geometrical inductance between the qubits. Also it is shown that coupling via a shared junction or a shared line acts the same as the geometrical coupling. Spectroscopy measurements show coupling for qubits which are mainly geometrical coupled and spectroscopy measurements on an other sample show a coupling for qubits coupled via a large shared Josephson junction. Using such a shared junction allows for the coupling to be designed within a large range. For the coupled qubit system with coupling via a large junction spectroscopy measurements from both the ground state to higher states as well as from the partially populated first excited state to higher states have been performed and the level structure of this system is mapped out. The energy level structure is in good agreement with the 4 level approximation for two coupled qubits. Coherent Rabi oscillations between two states flipping either qubit of this system have been performed with an oscillation decay time of up to 70ns. Also conditional spectroscopy has been performed by first going coherently from the ground state to a higher state and then incoherently pumping the system to other states. Spectroscopy measurements on a gradiometer type Josephson persistent current qubit show trapped fluxoid biasing can be used to create a phase bias of pi over the qubit junctions. The results of this thesis show that coupling between Josephson persistent current qubits can be achieved and designed within the wanted range. Superpositions between the ground state and higher states in such a coupled qubit system have been created by performing Rabi oscillations. Also conditional spectroscopy has been performed.