Physically-based hydrological-geotechnical modeling at large scales is difficult, especially due to the time-consuming nature of flow routing and 3D soil stability models. Although parallelization techniques are commonly used for each model individually, there is currently no concurrent parallelization strategy for both. This study proposed an open-source, Parallelized, and modular modeling software for regional Hydrologic processes and Landslides simulation and prediction (PHyL v1.0). It offers parallel computation in both hydrological and 3D slope stability modules, cross-scale modeling ability via a soil moisture downscaling method, and advanced input/output (I/O) and post-processing visualization. Additionally, PHyL v1.0 is flexible and extensible, making it compatible with all mainstream operating systems. We applied PHyL v1.0 in the Yuehe River Basin, where the computational efficiencies, parallel performance, parameter sensitivity analysis, and predictive capabilities were evaluated. The PHyL v1.0 is therefore appropriately used as an advanced software for high-resolution and complex simulations of regional floods and landslides.