There are obstacles in better understanding the climate impacts associated with new materials that could be used for Stratospheric Aerosol Injections (SAI), like the lack of an integrated framework that combines climate modeling across scales, laboratory studies and small-scale field experiments. Vattioni et al. (2023, https://doi.org/10.1029/2023gl105889) explored one aspect of using alternative, non-sulfate materials for SAI. They investigated how uncertain the response of stratospheric ozone would be to alumina injections for SAI. In their study, they quantify chlorine activation rates in the presence of alumina, and then cascade these uncertainties into estimates of ozone depletion, concluding that alumina might have less detrimental impacts on stratospheric chemistry than sulfate, but with large uncertainties. Their results provide a useful basis upon which future research endeavors combining indoor and outdoor experiments and modeling may be structured to produce robust assessments of SAI impacts, benefits and uncertainties, together with clarifying what kind of research needs to be prioritized.