The demand for high-rise building has been increasing over the past decades which has induced new developments such as modular construction. Modular construction has advantages in terms increased speed, safer construction and less construction waste. Applying modular construction in high-rise however brings about great complexities for the structural design of the building. Therefore, a design aid is created which generates a structural model from any arbitrary shape and uses structural optimization techniques to explore a range of designs for the early design stage. Existing optimization techniques have been studied, including Cross-Section (CS-) optimization (size) and BESO (topology). CS-optimization adapts the size of each member, considering utilization and displacement conditions whereas BESO removes or adds elements from the model based on stress level and Target Ratio (TR). Performing the methods successively further decreases the structural weight at certain TR. Generally, weight increases as more elements are removed. By developing the two-way coupled ESO<>CS-optimization method, elements are removed by lowest strain energy density, while the cross-sections of the remaining members are updated in each iteration, thus coupling ESO (topology) and CS-optimization (size). This results in a logical load path and additional weight reduction especially in the braced frame structures loaded by lateral loads when displacement is governing. In multiple load case design, the removal of elements is somewhat hard to interpret, however the method consistently results in the lowest structural weight for the considered cases. In order to create a modular structural design, boundary conditions are assumed by standardizing column and beam dimensions and considering multiple realistic load cases (wind+vertical load). By transforming arbitrary shapes into structural models and optimizing these, a range of solutions for the structural design is presented in which the number of elements and the structural weight are generally negatively related. For the considered rectangular buildings, the results are more efficient than core or outrigger structures and almost as efficient as mega frame structures, with the added benefit that it can be applied to any shape. Exploration of these solutions is a useful contribution to the early design stage of modular high-rise buildings, while the coupled ESO<>CS-optimization method could also be useful in other optimization problems.