Terrestrial and oceanic geothermal areas emit substantial amounts of hydrocarbons in the form of methane and the short-chain alkanes ethane and propane. Under hydrothermal conditions, these alkanes can also be oxidised to their respective alcohols and ketones, with a preference for the 2-position. The thermoacidophilic verrucomicrobial methanotroph Methylacidiphilum fumariolicum SolV, isolated from the Solfatara volcano, was previously shown to oxidise methane as well as the short-chain hydrocarbons propane and ethane. Here, we show the growth of strain SolV on the C3 compounds 2-propanol and acetone with growth rates of 0.054 h⁻¹ and 0.042 h⁻¹, respectively. In contrast to methanotrophic growth (rate 0.07 h⁻¹), growth was not dependent on CO₂ or lanthanides. Respiration experiments on steady-state continuous cultures showed an apparent affinity of 0.4 μM acetone and 5.4 μM 2-propanol. Transcriptomic analysis of these cultures showed that a gene cluster including a novel acetone monooxygenase (PMO3), previously identified in the closely related species Methylacidiphilum caldifontis, was highly upregulated under growth on C3 substrates. These results support the versatile metabolism of verrucomicrobial methanotrophs. The conversion of other compounds besides methane can be important in view of the ecological relevance of methanotrophs.