Effective planning and control are crucial for the successful delivery of engineering, procurement, and construction (EPC) projects, which are characterized by complex organizational structures, interdependent activities, overlapping phases, and a large number of disciplines and participants. However, project uncertainty, including the lack of complete information and frequent changes, can lead to delays and cost overruns if not effectively managed. In this research, an integrated planning and control approach for EPC projects that addresses these challenges by combining the Last Planner System of Lean Construction and the Scrum framework of Agile Management is developed. Through a literature review and a case study of an EPC industrial construction project, six requirements for effective planning and control and mechanisms for their implementation are identified. The approach is evaluated through interviews with industry experts. The results highlight the importance of both structured planning and control for identifiable and predictable uncertainties, and flexibility and agility for unforeseen uncertainties, in managing project uncertainty in EPC projects.