MXenes are a new family of 2D carbides or nitrides that have attracted attention due to their layered structure, tunable surface groups and high electrical conductivity. Here, we report for the first time that the Ti₂CT_x MXene catalyses the selective oxidative dehydrogenation of n-butane to butenes and 1,3-butadiene. This catalyst showed higher intrinsic activity compared to a commercial TiC and TiO₂ samples in terms of C₄ olefin formation rate. We propose that the stabilisation of structural vacancies and the change in composition (from a carbide to a mixed phase oxide) in the MXene causes its higher catalytic activity. These vacancies can lead to a higher concentration of unpaired electrons in the MXene-derived material, enhancing its nucleophilic properties and favouring the production of olefins.