This study investigates the parametric optimization of multiple-tuned mass dampers (MTMDs) deployed along the length of a tower and monopile structure subjected to stochastic wind and wave forces. The structural components, comprising the tower and monopile, are conceptualized as Euler–Bernoulli beams. The interaction with the soil is modeled through viscoelastic springs distributed along the monopile. The rotor nacelle assembly (RNA) and blades are abstracted into a concentrated mass at the tower's apex. The MTMDs are characterized as spring–mass–dashpot systems strategically positioned at intervals along the tower and monopile. The investigation involves a random vibration analysis under wind and wave loads, employing the Kaimal spectrum for wind and the JONSWAP spectrum for waves. The study focuses on optimizing the TMD parameters using H2 optimization techniques, with the optimization criteria being the minimization of the standard deviation of the tower's top displacement response. Additionally, meta-heuristic algorithms like the genetic algorithm (GA) are utilized to refine the determination of these optimal parameters. A key aspect of the research includes a parametric study that reveals variations in optimal parameters as the number of TMDs is altered, maintaining a consistent total mass across the MTMDs.