The diagrid structural system has seen significant uptake in medium to high rise buildings because of the architectural and resource advantages that it provides. These arise mainly as a result of flexibility in the topology that this particular structural solution provides. However, as a result of the way in which diagrids carry both horizontal and vertical loading, the diagrid structure itself may be susceptible to fire in ways which are not immediately obvious on the basis of our understanding of more traditional rectilinear construction forms. This study addresses this to improve our understanding of diagrid structures' response to fire. A comprehensive structural analysis on 45 fire load cases is conducted, considering different fire locations and sizes, using parametric design tools and finite element analysis software. The results provide valuable insights into the load redistribution and collapse mechanisms of diagrid structures in fire conditions.