Seasonal variation of air quality in a city with a large river was investigated by means of numerical simulations of air movement and pollutant dispersion over inversion-capped diurnal cycles using a Reynolds-averaged Navier-Stokes (RANS) approach with algebraic turbulent flux model. The study accounts for the effects of urban heat island (UHI), terrain orography and high thermal inertia of the river body. The case mimics the real environment of the Krasnoyarsk region with the river Yenisei (Russia). Two scenarios were considered typical of the winter and summer seasons. The study is focused on the dynamics of dispersion of CO emanating mainly from road traffic, which remains fairly uniform throughout the year. The simulation starts from a mild low-altitude inversion with penetrative convection gradually developing over the daytime and attenuating during the night. The main difference between the two cases is in the temperature of the river surface relative to the ambient air. In winter, the non-freezing river acts as a source of positive thermal buoyancy, while in summer the cool river at the daytime acts in the opposite way, as a heat sink. The effect of the river-induced air circulation appears significant enough to account for the observed winter accumulation of the pollutant in the city center.