It is known that the elderly usually spend the last years of their lives indoors, with little contact with others and the outside environment. Indoor environmental quality (IEQ) conditions related to lighting, air quality, thermal comfort, and acoustics directly affect their quality of life. In this study, the main focus is on the design of institutional care rooms for elderly people to create an indoor comfort. However, considering all four factors of IEQ in one model is a challenging task. A multi-objective problem is formulated based on a weighted sum of IEQ components in a parametric modelling environment using computational design methods. Several simulation tools are utilised, and a Self-Adaptive Ensemble Differential Evolution Algorithm is proposed to tackle this complex problem. The results show that optimal ranges for each IEQ component are achieved, with average values reaching 72% of the ideal benchmarks after the algorithm is converged. Results reveal strong correlations between IEQ components. This significant improvement in indoor environmental quality (IEQ) demonstrates the efficacy of the optimisation algorithm used. This study emphasises the flexibility and relevance of these findings for wider implementation in similar settings.@en