The escalating challenges caused by the climate change, notably floods and heatwaves, highlights the urgent need for robust resilience strategies in infrastructure and urban ecosystems. this research identifies critical gaps in existing methodologies and tools for assessing resilience, particularly during extreme events. Key issues include the absence of specialized tool for facade resilience quantification, limited multi-hazard assessment methodologies and a scarcity of quantitative methods in existing literature. In order to fill these gaps, this study formulates a research question: How can we identify the optimal facade combination that is resilient against heatwaves and floods? A quantitative approach is employed, integrating an interdisciplinary perspective that encompasses structural design, facade design, climate design and hazard engineering. The methodology involves an extensive literature review, computational simulations, machine learning models, sensitivity analysis and resilience matrix for quantification of flood and heatwaves resilient facade system. This study fills crucial gaps by offering a framework to assess facade resilience against these hazards. It identifies influential facade parameters and primary hazard stressors, crucial for informed decision-making by designers and engineers. The study culminates in a resilience quantification for multi-hazard assessment, empowering stakeholders to design resilient facade systems tailored to specific environmental contexts. The research findings contribute to advancing knowledge in building facade resilience, offering practical guidance for enhancing resilience in the face of evolving environmental challenges.