The current weaknesses of the conventional intermodal freight transportation system have led to the development of the synchromodal freight transportation concept introduced and piloted in the Netherlands. The innovative concept has the advantage of adding flexibility, cost reduction, and sustainability among other things, into the freight transportation system. The synchromodal system has not been started in any developing country yet due to its newness. In this study, we used multiple methodologies to conduct a feasibility study for the possibilities of introducing the concept in a developing country, Ghana. An intensive literature review was performed using the Grounded Theory and the Critical Success Factors (CSFs) method to identify the key factors for the introduction of the synchromodal concept. Questionnaires were administered to the primary stakeholders in the maritime-hinterland transportation sector to solicit their views about the factors necessary for the implementation. We next carried out SWOT (Strengths, Weaknesses, Opportunities, and Threats) analysis to catalogue the strengths and weakness of the country in introducing the concept. The multiple regression analysis method was used to analyse the experience of stakeholders in the freight transportation business and their knowledge about the synchromodal freight transportation system. The results of the study show that it is possible to introduce the concept in the country. However, there is the need to improve the current transportation and ports infrastructure of the country considerably for successful synchromodal system adaptation. There is also the need for stakeholders education on the concept.@en