Social infrastructure is crucial in repairing the fractured societies of today. Fragmentation of lifestyles has resulted in limited social networks between people from different backgrounds. A robust social infrastructure is critical to provide social connections and prevent friction between social groups, especially in multicultural settings. This research aims to identify the conditions that contribute to a robust social infrastructure when combining residential and manufacturing spaces. The focus is on the social infrastructure within a neighborhood, a mixed-use building block, and a residential building. The research is divided into three parts, developing a theoretical framework, investigating the neighborhood of Kralingen West in Rotterdam, and analyzing mixed-use and dwelling case studies. The neighborhood investigation contains participant observations. The participant observation gives insight into the spatial and programmatic qualities that resonate with social interaction. The research supports a design assignment in Merwevierhavens Rotterdam, which involves a mixed-use development combining urban manufacturing, residential settlements, and public facilities. The findings are translated into design strategies for the project. Public amenities are essential in promoting social cohesion in multicultural neighborhoods by providing opportunities for social interaction between different social groups. The layout of dwellings, where the dwellings are connected with the pubic environment, and specific spatial conditions also significantly stimulate social interaction and build trust between residents. Mixed-use development promotes social inclusion by encouraging public contact between different social groups. Transparent manufacturing and a common architectural language can contribute to a shared identity and promote a sense of belonging. At the same time, a central pedestrian area with spatial conditions that encourage social interaction is essential for encounters between user groups. Promoting social encounters and interaction in residential developments is essential for community building. An open circulation system and shared spaces provide these opportunities. The cooperative model allows for incorporating a generous circulation system and shared spaces by being user-oriented. Efficiently designed dwellings compensate for generously designed circulation and shared spaces.