This special section addresses Responsible Research and Innovation (RRI) as an increasingly global concept that is translated and transformed in heterogenous national contexts. Based on seven national perspective articles from the RRI-Practice project, this introduction outlines a framework of transduction through which RRI becomes contextually negotiated and reconfigured. Read together, the national explorations of the special section make visible aspects of responsibility not readily apparent in abstract, European or global scale discussions of RRI. They not only point up important particularities of national contexts, but unexpected points of overlap in national contexts not often thought to have distinct commonalities.@en